DMTr-protected Nucleosides
5'-O-DMTr-2'-F-dG(iBu)
Quick view. N2-Isobutyryl-2'-fluoro-2'-deoxyguanosine bearing a 5'-O-DMTr group with a free 3'-hydroxyl group. CAS 144089-96-3. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
5'-O-DMTr-2'-F-dG(iBu) is classified as dmtr-protected nucleosides (Formula C35H36FN5O7; molecular weight 657.70).
5'-O-DMTr-2'-F-dG(iBu) is commonly assessed in siRNA, antisense and aptamer-style designs where ribose modification is used to tune stability and binding.
For 5'-O-DMTr-2'-F-dG(iBu), coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Confirmed or normalized name variants
- 5'-O-(4,4'-Dimethoxytrityl)-2'-fluoro-N2-isobutyryl-2'-deoxyguanosine
- 5'-O-DMT-N2-iBu-2'-F-dG
Useful catalog search terms
- N2-Isobutyryl-5'-O-DMTr-2'-fluoro-2'-deoxyguanosine
- CAS 144089-96-3
Physicochemical data
| Nucleoside | N2-Isobutyryl-2'-fluoro-2'-deoxyguanosine |
|---|---|
| Hydroxyl protection | 5'-O-DMTr |
| Hydroxyl state | 3' hydroxyl group unprotected |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 5'-O-DMTr-2'-F-dG(iBu) or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
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BX-PN-00265'-O-DMTr-2'-F-dC(Bz)
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Frequently asked questions
Can the package size for 5'-O-DMTr-2'-F-dG(iBu) be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-PN-0063 and CAS 144089-96-3, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the DMTr-protected Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.