DMTr-protected Nucleosides
5'-O-DMTr-2'-O-4'-C-Locked-5-Me-rC(Bz)
Quick view. We supply 5'-O-DMTr-2'-O-4'-C-Locked-5-Me-rC(Bz) as a DMT-protected LNA 5-methylcytidine intermediate for preparing LNA phosphoramidites and affinity-enhancing oligonucleotide monomers. CAS 445012-77-1. Catalog target purity: ≥95%.
Product profile
5'-O-DMTr-2'-O-4'-C-Locked-5-Me-rC(Bz) is classified as nucleoside or protected nucleoside intermediate (Formula C39H37N3O8; molecular weight 675.74).
5'-O-DMTr-2'-O-4'-C-Locked-5-Me-rC(Bz) can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 5'-O-DMTr-2'-O-4'-C-Locked-5-Me-rC(Bz), high-affinity monomers require careful positional design; over-substitution may increase off-target binding or complicate synthesis.
Names and search terms
Confirmed or normalized name variants
- 5'-DMTr-LNA-N4-Bz-methyl-C
- N4-Benzoyl-5’-O-(4,4’-dimethoxytrityl)-5-methyl-2’-O,4’-C-methylenecytidine
- N4-Banzoyl-5'-O-(4,4'-dimethoxytrityl)-5-methyl-2'-O,4'-C-methylenecytidine
- 5'-O-DMT-2'-O-4'-C-Locked-5-Me-rC(Bz)
Useful catalog search terms
- CAS 445012-77-1
- Nucleoside or protected nucleoside intermediate
- DMTr/DMT protection
- conformationally locked sugar
- DMTr-protected Nucleosides
Physicochemical data
| Key chemistry motifs | DMTr/DMT protection; conformationally locked sugar |
|---|
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
- We release this product against the stated purity specification; the lot-specific CoA provides the result and analytical basis.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- Locked/bicyclic sugar motifs can substantially increase duplex thermal stability and mismatch discrimination.
Method limitations
- High-affinity monomers require careful positional design; over-substitution may increase off-target binding or complicate synthesis.
These points describe 5'-O-DMTr-2'-O-4'-C-Locked-5-Me-rC(Bz) or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
3'-O-DMTr-2'-O-Me-rG(iBu)
DMTr-protected Nucleosides · CAS: N/A
BX-PN-00193'-O-DMTr-2'-O-Me-rU
DMTr-protected Nucleosides · CAS: N/A
BX-PN-00203'-O-DMTr-dA(Bz)
DMTr-protected Nucleosides · CAS: 140712-79-4
BX-PN-00265'-O-DMTr-2'-F-dC(Bz)
DMTr-protected Nucleosides · CAS: N/A
BX-PN-00275'-O-DMTr-2'-O-(2-aminoethyl) -5-Me-rU
DMTr-protected Nucleosides · CAS: 242147-79-1
BX-PN-00285'-O-DMTr-2'-O-(2-cyanoethoxymethyl)-rA(Ac)
DMTr-protected Nucleosides · CAS: 863408-41-7
Frequently asked questions
Can the package size for 5'-O-DMTr-2'-O-4'-C-Locked-5-Me-rC(Bz) be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-PN-0032 and CAS 445012-77-1, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-relevant literature
The publications below discuss 5'-O-DMTr-2'-O-4'-C-Locked-5-Me-rC(Bz) or the named structural feature represented by this product.