DMTr-protected Nucleosides
5'-O-DMTr-2'-O-4'-C-Locked-rG(dmf)
Quick view. We supply 5'-O-DMTr-2'-O-4'-C-Locked-rG(dmf) as a DMT-protected, DMF-protected LNA guanosine intermediate for locked guanine phosphoramidite synthesis. CAS 709641-78-1. Catalog target purity: ≥95%.
Product profile
5'-O-DMTr-2'-O-4'-C-Locked-rG(dmf) is classified as nucleoside or protected nucleoside intermediate (Formula C35H36N6O7; molecular weight 652.71).
5'-O-DMTr-2'-O-4'-C-Locked-rG(dmf) can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 5'-O-DMTr-2'-O-4'-C-Locked-rG(dmf), high-affinity monomers require careful positional design; over-substitution may increase off-target binding or complicate synthesis.
Names and search terms
Confirmed or normalized name variants
- 5'-ODMT-LNA-G
- 5'-O-DMT-2'-O-4'-C-Locked-rG(dmf)
- 2'-O-4'-C-Locked-rG(dmf)
- BX-PN-0008
Useful catalog search terms
- CAS 709641-78-1
- Nucleoside or protected nucleoside intermediate
- DMTr/DMT protection
- conformationally locked sugar
- DMTr-protected Nucleosides
Physicochemical data
| Key chemistry motifs | DMTr/DMT protection; conformationally locked sugar |
|---|---|
| Boiling point | 858.1±75.0 °C(Predicted) |
| Density | 1.38±0.1 g/cm3(Predicted) |
| pKa | 13.01±0.60(Predicted) |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
- We release this product against the stated purity specification; the lot-specific CoA provides the result and analytical basis.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- Locked/bicyclic sugar motifs can substantially increase duplex thermal stability and mismatch discrimination.
Method limitations
- High-affinity monomers require careful positional design; over-substitution may increase off-target binding or complicate synthesis.
These points describe 5'-O-DMTr-2'-O-4'-C-Locked-rG(dmf) or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 5'-O-DMTr-2'-O-4'-C-Locked-rG(dmf) be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-PN-0035 and CAS 709641-78-1, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-relevant literature
The publications below discuss 5'-O-DMTr-2'-O-4'-C-Locked-rG(dmf) or the named structural feature represented by this product.