DMTr-protected Nucleosides
5'-O-DMTr-2'-O-Me-rA
Quick view. 2'-O-Methyladenosine bearing a 5'-O-DMTr group with a free 3'-hydroxyl group and an unprotected adenine base. CAS 103285-23-0. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
5'-O-DMTr-2'-O-Me-rA is classified as dmtr-protected nucleosides (Formula C32H33N5O6; molecular weight 583.65).
5'-O-DMTr-2'-O-Me-rA supports modified RNA/antisense designs where methylated ribose positions are used to improve stability or reduce unwanted immune stimulation.
For 5'-O-DMTr-2'-O-Me-rA, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Confirmed or normalized name variants
- 5'-O-DMTr-2'-O-methyladenosine
- 5'-O-DMT-2'-O-Me-rA
Useful catalog search terms
- CAS 103285-23-0
Physicochemical data
| Nucleoside | 2'-O-Methyladenosine |
|---|---|
| Hydroxyl protection | 5'-O-DMTr |
| Hydroxyl state | 3' hydroxyl group unprotected |
| Base state | Adenine N6-amino group unprotected |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 5'-O-DMTr-2'-O-Me-rA or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
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Frequently asked questions
Can the package size for 5'-O-DMTr-2'-O-Me-rA be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-PN-0077 and CAS 103285-23-0, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the DMTr-protected Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.