DMTr-protected Nucleosides
5'-O-DMTr-2'-O-Me-rC(Bz)
Quick view. We supply 5'-O-DMTr-2'-O-Me-rC(Bz) as a protected 2'-O-methyl cytidine intermediate for RNA and ASO monomer synthesis. CAS 110764-74-4. Catalog target purity: ≥98%.
Product profile
5'-O-DMTr-2'-O-Me-rC(Bz) is classified as nucleoside or protected nucleoside intermediate (Formula C38H37N3O8; molecular weight 663.72).
5'-O-DMTr-2'-O-Me-rC(Bz) — N4-Benzoyl-5''-O-(4,4''-dimethoxytrityl)-2''-O-methycytidine (CAS# 110764-74-4) is a nucleoside used in the synthesis of fluorocarbon oligonucleotide conjugates which allow for the delivery of nucleic acids into human cells. N4-Benzoyl-5''-O-(4,4''-dimethoxytrityl)-2''-O-methycytidine is also used in the preparation of RNA and RNA…
For 5'-O-DMTr-2'-O-Me-rC(Bz), storage: 2-8°C. Form: Solid.
Names and search terms
Confirmed or normalized name variants
- 5'-O-DMT-N4-Bz-2'-OMe-rC
- 5-O-DMT-N4-BENZOYL-2-O-METHYL-CYTIDINE
- N4-Benzoyl-5'-O-(4,4'-diMethoxytrityl)-2'-O-Methycytidine
- N-Benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methylcytidine
- Cytidine, N-benzoyl-5'-O-[bis(4-Methoxyphenyl)phenylMethyl]-2'-O-Methyl-
- 5'-O-DMT-2'-O-Me-rC(Bz)
Useful catalog search terms
- CAS 110764-74-4
- Nucleoside or protected nucleoside intermediate
- DMTr/DMT protection
- 2'-O-methyl modification
- DMTr-protected Nucleosides
Physicochemical data
| Key chemistry motifs | DMTr/DMT protection; 2'-O-methyl modification |
|---|---|
| Density | 1.27±0.1 g/cm3(Predicted) |
| pKa | 8.58±0.20(Predicted) |
| Form | Solid |
| Color | White to off-white |
| InChI | InChI=1S/C38H37N3O8/c1-45-29-18-14-27(15-19-29)38(26-12-8-5-9-13-26,28-16-20-30(46-2)21-17-28)48-24-31-33(42)34(47-3)36(49-31)41-23-22-32(40-37(41)44)39-35(43)25-10-6-4-7-11-25/h4-23,31,33-34,36,42H,24H2,1-3H3,(H,39,40,43,44)/t31-,33-,34-,36-/m1/s |
| InChIKey | WXJKGOQQYUVNQW-YDXJMRNDSA-N |
| SMILES | CO[C@@H]1[C@@H]([C@H](O[C@H]1N2C=CC(=NC2=O)NC(=O)C3=CC=CC=C3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)O |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
- We release this product against the stated purity specification; the lot-specific CoA provides the result and analytical basis.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- 5'-O-DMTr-2'-O-Me-rC(Bz) can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 5'-O-DMTr-2'-O-Me-rC(Bz) or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
3'-O-DMTr-2'-O-Me-rG(iBu)
DMTr-protected Nucleosides · CAS: N/A
BX-PN-00193'-O-DMTr-2'-O-Me-rU
DMTr-protected Nucleosides · CAS: N/A
BX-PN-00203'-O-DMTr-dA(Bz)
DMTr-protected Nucleosides · CAS: 140712-79-4
BX-PN-00265'-O-DMTr-2'-F-dC(Bz)
DMTr-protected Nucleosides · CAS: N/A
BX-PN-00275'-O-DMTr-2'-O-(2-aminoethyl) -5-Me-rU
DMTr-protected Nucleosides · CAS: 242147-79-1
BX-PN-00285'-O-DMTr-2'-O-(2-cyanoethoxymethyl)-rA(Ac)
DMTr-protected Nucleosides · CAS: 863408-41-7
Frequently asked questions
Can the package size for 5'-O-DMTr-2'-O-Me-rC(Bz) be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-PN-0041 and CAS 110764-74-4, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the DMTr-protected Nucleosides product family and its named chemistry.