DMTr-protected Nucleosides
N2-Isobutyryl-5'-O-DMTr-2'-O-methylguanosine
Quick view. A beta-D-guanosine building block bearing N2-isobutyryl and 5'-O-DMTr protection, a 2'-O-methyl substituent, and a free 3'-hydroxyl group. CAS 114745-26-5. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
N2-Isobutyryl-5'-O-DMTr-2'-O-methylguanosine is classified as dmtr-protected nucleosides (Formula C36H39N5O8; molecular weight 669.74).
N2-Isobutyryl-5'-O-DMTr-2'-O-methylguanosine — Identity-defined protected nucleoside building block for research workflows involving nucleoside, nucleotide, and oligonucleotide chemistry.
For N2-Isobutyryl-5'-O-DMTr-2'-O-methylguanosine, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Confirmed or normalized name variants
- 5'-O-DMTr-2'-O-Me-rG(iBu)
- 5'-O-DMT-N2-isobutyryl-2'-O-methyl-D-guanosine
- DMT-2'-OMe-iBu-rG
Useful catalog search terms
- CAS 114745-26-5
- PubChem CID 14991812
Physicochemical data
| PubChem CID | 14991812 |
|---|---|
| InChIKey | ISQLJOGRNUQHJX-QTXIGGTANA-N |
| Nucleoside | beta-D-Guanosine |
| Ribofuranosyl stereochemistry | (2R,3R,4R,5R) |
| Base protection | N2-Isobutyryl |
| 5' protection | DMTr |
| Sugar modification | 2'-O-Methyl |
| Free hydroxyl group | 3' |
| InChI | InChI=1S/C36H39N5O8/c1-21(2)32(43)39-35-38-31-28(33(44)40-35)37-20-41(31)34-30(47-5)29(42)27(49-34)19-48-36(22-9-7-6-8-10-22,23-11-15-25(45-3)16-12-23)24-13-17-26(46-4)18-14-24/h6-18,20-21,27,29-30,34,42H,19H2,1-5H3,(H2,38,39,40,43,44)/t27-,29-,30-,34-/m1/s1 |
| SMILES | COc1ccc(C(OC[C@H]2O[C@@H](n3cnc4c(O)nc(NC(=O)C(C)C)nc43)[C@H](OC)[C@@H]2O)(c2ccccc2)c2ccc(OC)cc2)cc1 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe N2-Isobutyryl-5'-O-DMTr-2'-O-methylguanosine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for N2-Isobutyryl-5'-O-DMTr-2'-O-methylguanosine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-PN-0108 and CAS 114745-26-5, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the DMTr-protected Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.