DMTr-protected Nucleosides
5'-O-DMTr-2'-O-MOE-5-Me-rC(Bz)
Quick view. We supply 5'-O-DMTr-2'-O-MOE-5-Me-rC(Bz) as a protected 2'-O-methoxyethyl 5-methylcytidine intermediate for MOE phosphoramidite synthesis. CAS 182496-01-1. Catalog target purity: ≥95%.
Product profile
5'-O-DMTr-2'-O-MOE-5-Me-rC(Bz) is classified as nucleoside or protected nucleoside intermediate (Formula C41H43N3O9; molecular weight 721.79).
5'-O-DMTr-2'-O-MOE-5-Me-rC(Bz) can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 5'-O-DMTr-2'-O-MOE-5-Me-rC(Bz), mOE placement needs design control, especially when RNase H recruitment or steric profile matters.
Names and search terms
Confirmed or normalized name variants
- 5'-O-DMT-2'-O-MOE-N4-Bz-5-Me-C
- 5'-O-DMT-2’-MOE-N6-Bz-5-Methycytidine
- 5'-O-DMT-N4-Benzoyl-5-methyl-2'-O-(2-methoxyethyl)cytidine
- N4-Benzoyl-5'-O-DMT-2'-O-(2-Methoxyethyl)-5-methylcytidine
- N-benzoyl-5'-O-DMTr-2'-O-(2-Methoxyethyl)-5-Methyl Cytidine
- N-Benzoyl-2'-O-methoxyethyl-5-O-dimethoxytrityl-5-methylcytidine
- N4-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(2-methoxyethyl)-5-methylcytidine
- 5'-O-(4,4'-dimethoxytriphenylmethyl)-2'-O-(2-methoxyethyl)-N4-benzoyl-5-methylcytidine
Useful catalog search terms
- CAS 182496-01-1
- Nucleoside or protected nucleoside intermediate
- DMTr/DMT protection
- 2'-O-MOE modification
- DMTr-protected Nucleosides
Physicochemical data
| Key chemistry motifs | DMTr/DMT protection; 2'-O-MOE modification |
|---|---|
| Density | 1.26 |
| pKa | 8.60±0.40(Predicted) |
| SMILES | O(C(C1=CC=C(OC)C=C1)(C1=CC=C(OC)C=C1)C1=CC=CC=C1)C[C@H]1O[C@@H](N2C=C(C)C(NC(=O)C3=CC=CC=C3)=NC2=O)[C@H](OCCOC)[C@@H]1O |&1:25,27,45,51,r| |
| InChIKey | BYSCLUAIKFEFAH-QYBFQDRGNA-N |
| InChI | InChI=1S/C41H43N3O9/c1-27-25-44(40(47)43-37(27)42-38(46)28-11-7-5-8-12-28)39-36(51-24-23-48-2)35(45)34(53-39)26-52-41(29-13-9-6-10-14-29,30-15-19-32(49-3)20-16-30)31-17-21-33(50-4)22-18-31/h5-22,25,34-36,39,45H,23-24,26H2,1-4H3,(H,42,43,46,47)/t34-,35-,36-,39-/m1/s |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
- We release this product against the stated purity specification; the lot-specific CoA provides the result and analytical basis.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- 2′-O-MOE motifs are often selected for enhanced nuclease resistance and improved duplex stability.
Method limitations
- MOE placement needs design control, especially when RNase H recruitment or steric profile matters.
These points describe 5'-O-DMTr-2'-O-MOE-5-Me-rC(Bz) or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 5'-O-DMTr-2'-O-MOE-5-Me-rC(Bz) be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-PN-0037 and CAS 182496-01-1, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the DMTr-protected Nucleosides product family and its named chemistry.