DMTr-protected Nucleosides
5'-O-DMTr-2'-O-MOE-rG(iBu)
Quick view. N2-isobutyryl-protected guanosine bearing a 5'-O-DMTr group, a 2'-O-(2-methoxyethyl) substituent and a free 3'-hydroxyl. CAS 251647-50-4. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
5'-O-DMTr-2'-O-MOE-rG(iBu) is classified as dmtr-protected nucleosides (Formula C38H43N5O9; molecular weight 713.78).
5'-O-DMTr-2'-O-MOE-rG(iBu) is relevant to high-stability antisense oligonucleotide gapmer and affinity-tuning research.
For 5'-O-DMTr-2'-O-MOE-rG(iBu), mOE placement needs design control, especially when RNase H recruitment or steric profile matters.
Names and search terms
Confirmed or normalized name variants
- 5'-O-DMTr-N2-isobutyryl-2'-O-(2-methoxyethyl)guanosine
- N2-iBu-DMT-2'-O-MOE-G
Useful catalog search terms
- CAS 251647-50-4
Physicochemical data
| Nucleoside | Guanosine |
|---|---|
| Nucleobase protection | N2-isobutyryl |
| Hydroxyl protection | 5'-O-DMTr |
| Sugar modification | 2'-O-(2-methoxyethyl) |
| Hydroxyl state | 3' hydroxyl group unprotected |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-MOE motifs are often selected for enhanced nuclease resistance and improved duplex stability.
Method limitations
- MOE placement needs design control, especially when RNase H recruitment or steric profile matters.
These points describe 5'-O-DMTr-2'-O-MOE-rG(iBu) or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
3'-O-DMTr-2'-O-Me-rG(iBu)
DMTr-protected Nucleosides · CAS: N/A
BX-PN-00193'-O-DMTr-2'-O-Me-rU
DMTr-protected Nucleosides · CAS: N/A
BX-PN-00203'-O-DMTr-dA(Bz)
DMTr-protected Nucleosides · CAS: 140712-79-4
BX-PN-00265'-O-DMTr-2'-F-dC(Bz)
DMTr-protected Nucleosides · CAS: N/A
BX-PN-00275'-O-DMTr-2'-O-(2-aminoethyl)-5-Me-rU
DMTr-protected Nucleosides · CAS: 242147-79-1
BX-PN-00285'-O-DMTr-2'-O-(2-cyanoethoxymethyl)-rA(Ac)
DMTr-protected Nucleosides · CAS: 863408-41-7
Frequently asked questions
Can the package size for 5'-O-DMTr-2'-O-MOE-rG(iBu) be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-PN-0040 and CAS 251647-50-4, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the DMTr-protected Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.