DMTr-protected Nucleosides
5'-O-DMTr-2'-O-MOE-rG(iBu)
Quick view. We supply 5'-O-DMTr-2'-O-MOE-rG(iBu) as an isobutyryl-protected MOE guanosine intermediate for modified oligonucleotide monomer synthesis. CAS 251647-50-4. Catalog target purity: ≥97%.
Product profile
5'-O-DMTr-2'-O-MOE-rG(iBu) is classified as nucleoside or protected nucleoside intermediate (Formula C38H43N5O9; molecular weight 713.78).
5'-O-DMTr-2'-O-MOE-rG(iBu) can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 5'-O-DMTr-2'-O-MOE-rG(iBu), mOE placement needs design control, especially when RNase H recruitment or steric profile matters.
Names and search terms
Confirmed or normalized name variants
- 5'-O-DMT-2’-MOE-N2-iBu-Guanosine
- N2-ISOBUTYRYL-5, O-(4,4 -DIMETHOXYTRITYL)-2 -O-(2
- 5'-O-DMT-N2-isobutyryl-2'-O-(2-methoxyethyl)guanosine
- N2-iso-Butyroyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(2-methoxyethyl)guanosine
- 5'-O-(4,4'-dimethoxytriphenylmethyl)-2'-O-(2-methoxyethyl)-N2-isobutyrylguanosine
- 5'-O-DMT-2'-O-MOE-rG(iBu)
Useful catalog search terms
- CAS 251647-50-4
- Nucleoside or protected nucleoside intermediate
- DMTr/DMT protection
- 2'-O-MOE modification
- DMTr-protected Nucleosides
Physicochemical data
| Key chemistry motifs | DMTr/DMT protection; 2'-O-MOE modification |
|---|---|
| Melting point | 112.5-126.6 °C(Solv: hexane (110-54-3)) |
| Density | 1.33±0.1 g/cm3(Predicted) |
| pKa | 9.16±0.20(Predicted) |
| SMILES | O(C(C1=CC=C(OC)C=C1)(C1=CC=C(OC)C=C1)C1=CC=CC=C1)C[C@H]1O[C@@H](N2C3=C(C(NC(=N3)NC(=O)C(C)C)=O)N=C2)[C@H](OCCOC)[C@@H]1O |&1:25,27,44,50,r| |
| InChIKey | XDLPRZLZAFJSMA-JKILKRELNA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
- We release this product against the stated purity specification; the lot-specific CoA provides the result and analytical basis.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- 2′-O-MOE motifs are often selected for enhanced nuclease resistance and improved duplex stability.
Method limitations
- MOE placement needs design control, especially when RNase H recruitment or steric profile matters.
These points describe 5'-O-DMTr-2'-O-MOE-rG(iBu) or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 5'-O-DMTr-2'-O-MOE-rG(iBu) be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-PN-0040 and CAS 251647-50-4, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the DMTr-protected Nucleosides product family and its named chemistry.