DMTr-protected Nucleosides
5'-O-DMTr-3'-O-Me-rA(Bz)
Quick view. N6-Benzoyladenosine bearing a 5'-O-DMTr group and a 3'-O-methyl group, with a free 2'-hydroxyl group. CAS 127212-38-8. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
5'-O-DMTr-3'-O-Me-rA(Bz) is classified as dmtr-protected nucleosides (Formula C39H37N5O7; molecular weight 687.70 g/mol).
5'-O-DMTr-3'-O-Me-rA(Bz) can be evaluated in terminally blocked nucleotide, cap-chemistry and analytical-reference workflows where 3′-O-methylation changes extension or end-group reactivity.
For 5'-O-DMTr-3'-O-Me-rA(Bz), the 3′-O-methyl group blocks normal 3′-hydroxyl extension; confirm that this behavior matches the intended enzyme or synthesis workflow.
Names and search terms
Confirmed or normalized name variants
- N6-Benzoyl-5'-O-DMTr-3'-O-methyladenosine
- 5'-O-DMT-3'-O-Me-rA(Bz)
Useful catalog search terms
- CAS 127212-38-8
- NS067-1
Physicochemical data
| Nucleoside | N6-Benzoyladenosine |
|---|---|
| Hydroxyl protection | 5'-O-DMTr |
| Sugar modification | 3'-O-methyl |
| Hydroxyl state | 2' hydroxyl group unprotected |
| SMILES | CO[C@@H]1[C@H](O[C@H]([C@@H]1O)N2C=NC3=C(N=CN=C32)NC(=O)C4=CC=CC=C4)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC |
| InChI | InChI=1S/C39H37N5O7/c1-47-29-18-14-27(15-19-29)39(26-12-8-5-9-13-26,28-16-20-30(48-2)21-17-28)50-22-31-34(49-3)33(45)38(51-31)44-24-42-32-35(40-23-41-36(32)44)43-37(46)25-10-6-4-7-11-25/h4-21,23-24,31,33-34,38,45H,22H2,1-3H3,(H,40,41,43,46)/t31-,33-,34-,38-/m1/s1 |
| PubChem CID | 127258200 |
| InChIKey | BXARQKKKQMVIEG-CJEGOSRCSA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 3′-O-methylation provides a defined blocked ribose terminus and is analytically distinguishable from the corresponding 2′-O-methyl isomer.
Method limitations
- The 3′-O-methyl group blocks normal 3′-hydroxyl extension; confirm that this behavior matches the intended enzyme or synthesis workflow.
These points describe 5'-O-DMTr-3'-O-Me-rA(Bz) or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 5'-O-DMTr-3'-O-Me-rA(Bz) be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-PN-0078 and CAS 127212-38-8, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the DMTr-protected Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.