Base-protected Nucleosides
rG(iBu)
Quick view. We supply rG(iBu) as a base- or sugar-protected nucleoside intermediate for nucleoside, nucleotide and oligonucleotide building-block synthesis. CAS 64350-24-9. Catalog target purity: Specification on request.
Product profile
rG(iBu) is classified as nucleoside or protected nucleoside intermediate (Formula C14H19N5O6; molecular weight 353.33).
rG(iBu) — N-Isobutyrylguanosine is used in the syntehsis of 2''-O-(o-nitrobenzyl)-3''-thioguanosine phosphoramidite which is then used to form oligonucleotides, substrates for probing the mechanism of RNA catalysis.
For rG(iBu), reported solubility: DMSO (Slightly), Methanol (Slightly). Storage: Store at 0°C.
Names and search terms
Confirmed or normalized name variants
- ibu-rG
- N2-iBu-rG
- N2-iBu-Gr
- N-Isobutyryl guanosine
- N2-(ISOBUTYRYL)-GUANOSINE
- N2-ISOBUTYRYL-D-GUANOSINE
- N-(2-Methylpropanoyl)guanosine
- N2-Isobutyrylguanosine Hydrate
Useful catalog search terms
- CAS 64350-24-9
- Nucleoside or protected nucleoside intermediate
- Base-protected Nucleosides
Physicochemical data
| Melting point | 148 °C |
|---|---|
| Density | 1.82±0.1 g/cm3(Predicted) |
| pKa | 9.16±0.20(Predicted) |
| Form | Solid |
| Color | White to Off-White |
| SMILES | OC[C@H]1O[C@@H](N2C3=C(C(NC(=N3)NC(=O)C(C)C)=O)N=C2)[C@H](O)[C@@H]1O |
| InChIKey | OXTYJSXVUGJSGM-HTVVRFAVSA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- rG(iBu) can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
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Frequently asked questions
Can the package size for rG(iBu) be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-PN-0102 and CAS 64350-24-9, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Base-protected Nucleosides product family and its named chemistry.