2'-O-MOE Nucleosides
2-Amino-2'-O-(2-methoxyethyl)adenosine
Quick view. Adenosine analogue bearing an additional amino group at purine C2 and a 2'-O-(2-methoxyethyl) substituent, with free 3'- and 5'-hydroxyl groups. CAS 256224-13-2. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
2-Amino-2'-O-(2-methoxyethyl)adenosine is classified as 2'-o-moe nucleosides (Formula C13H20N6O5; molecular weight 340.34 g/mol).
2-Amino-2'-O-(2-methoxyethyl)adenosine provides a reactive functional group for conjugation, immobilization or linker-extension studies.
For 2-Amino-2'-O-(2-methoxyethyl)adenosine, functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
Names and search terms
Confirmed or normalized name variants
- 2'-O-(2-Methoxyethyl)-2-aminoadenosine
Useful catalog search terms
- 256224-13-2
Physicochemical data
| Systematic name | (2R,3R,4R,5R)-5-(2,6-diaminopurin-9-yl)-2-(hydroxymethyl)-4-(2-methoxyethoxy)oxolan-3-ol |
|---|---|
| Chemical form | Neutral 2-amino-2'-O-MOE-modified adenosine |
| Structural scope | 2-amino purine and 2'-O-(2-methoxyethyl) substitution with free 3'- and 5'-hydroxyl groups |
| Stereochemical scope | Four defined ribose stereocenters |
| InChIKey | ZPWSGIIALWUBNX-WOUKDFQISA-N |
| InChI | InChI=1S/C13H20N6O5/c1-22-2-3-23-9-8(21)6(4-20)24-12(9)19-5-16-7-10(14)17-13(15)18-11(7)19/h5-6,8-9,12,20-21H,2-4H2,1H3,(H4,14,15,17,18)/t6-,8-,9-,12-/m1/s1 |
| SMILES | COCCO[C@@H]1[C@@H]([C@H](O[C@H]1N2C=NC3=C(N=C(N=C32)N)N)CO)O |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- Reactive handles make the product adaptable across dye-labeling, surface-coupling and ligand-conjugation workflows.
- 2′-O-MOE motifs are often selected for enhanced nuclease resistance and improved duplex stability.
Method limitations
- Functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
- MOE placement needs design control, especially when RNase H recruitment or steric profile matters.
These points describe 2-Amino-2'-O-(2-methoxyethyl)adenosine or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
2'-O-(2-Methoxyethyl)inosine
2'-O-MOE Nucleosides · CAS: 545374-76-3
BX-MN-01672'-O-(2-Methoxyethyl)-5-methylcytidine
2'-O-MOE Nucleosides · CAS: 244105-55-3
BX-MN-01682'-O-(2-Methoxyethyl)guanosine
2'-O-MOE Nucleosides · CAS: 473278-54-5
BX-MN-01692'-O-(2-Methoxyethyl)adenosine
2'-O-MOE Nucleosides · CAS: 168427-74-5
BX-MN-01702'-O-(2-Methoxyethyl)cytidine
2'-O-MOE Nucleosides · CAS: 223777-16-0
BX-MN-01712'-O-(2-Methoxyethyl)uridine
2'-O-MOE Nucleosides · CAS: 223777-15-9
Frequently asked questions
Can the package size for 2-Amino-2'-O-(2-methoxyethyl)adenosine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2MOE-0017 and CAS 256224-13-2, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the 2'-O-MOE Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.