2'-O-MOE Nucleosides
3'-O-(4,4'-Dimethoxytrityl)-N2-isobutyryl-2'-O-(2-methoxyethyl)guanosine
Quick view. A protected 2'-O-MOE guanosine intermediate bearing N2-isobutyryl base protection and a 3'-O-DMTr group, with the 5'-hydroxymethyl group unprotected. A public CAS number is not assigned for this exact form. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
3'-O-(4,4'-Dimethoxytrityl)-N2-isobutyryl-2'-O-(2-methoxyethyl)guanosine is classified as protected 2'-o-moe guanosine (Formula C38H43N5O9; molecular weight 713.78 g/mol).
3'-O-(4,4'-Dimethoxytrityl)-N2-isobutyryl-2'-O-(2-methoxyethyl)guanosine is relevant to high-stability antisense oligonucleotide gapmer and affinity-tuning research.
For 3'-O-(4,4'-Dimethoxytrityl)-N2-isobutyryl-2'-O-(2-methoxyethyl)guanosine, mOE placement needs design control, especially when RNase H recruitment or steric profile matters.
Names and search terms
Confirmed or normalized name variants
- 3'-O-DMTr-N2-isobutyryl-2'-O-MOE guanosine
- 3'-O-DMT-2'-O-MOE-G(iBu)
Physicochemical data
| Ribose substitution | 2'-O-(2-methoxyethyl) |
|---|---|
| Protection pattern | 3'-O-DMTr; N2-isobutyryl |
| 5' position | Hydroxymethyl group unprotected |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-MOE motifs are often selected for enhanced nuclease resistance and improved duplex stability.
Method limitations
- MOE placement needs design control, especially when RNase H recruitment or steric profile matters.
These points describe 3'-O-(4,4'-Dimethoxytrityl)-N2-isobutyryl-2'-O-(2-methoxyethyl)guanosine or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
2'-O-(2-Methoxyethyl)inosine
2'-O-MOE Nucleosides · CAS: 545374-76-3
BX-MN-01672'-O-(2-Methoxyethyl)-5-methylcytidine
2'-O-MOE Nucleosides · CAS: 244105-55-3
BX-MN-01682'-O-(2-Methoxyethyl)guanosine
2'-O-MOE Nucleosides · CAS: 473278-54-5
BX-MN-01692'-O-(2-Methoxyethyl)adenosine
2'-O-MOE Nucleosides · CAS: 168427-74-5
BX-MN-01702'-O-(2-Methoxyethyl)cytidine
2'-O-MOE Nucleosides · CAS: 223777-16-0
BX-MN-01712'-O-(2-Methoxyethyl)uridine
2'-O-MOE Nucleosides · CAS: 223777-15-9
Frequently asked questions
Can the package size for 3'-O-(4,4'-Dimethoxytrityl)-N2-isobutyryl-2'-O-(2-methoxyethyl)guanosine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2MOE-0018, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the 2'-O-MOE Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.