2'-O-MOE Nucleosides
3'-O-TBDMS-2'-O-MOE-5-methyluridine
Quick view. A beta-D-ribofuranosyl 5-methyluridine derivative with 2'-O-MOE substitution and 3'-O-TBDMS protection, CAS 1221967-92-5. CAS 1221967-92-5. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
3'-O-TBDMS-2'-O-MOE-5-methyluridine is classified as 2'-o-moe nucleosides (Formula C19H34N2O7Si; molecular weight 430.57).
3'-O-TBDMS-2'-O-MOE-5-methyluridine is relevant to high-stability antisense oligonucleotide gapmer and affinity-tuning research.
For 3'-O-TBDMS-2'-O-MOE-5-methyluridine, mOE placement needs design control, especially when RNase H recruitment or steric profile matters.
Names and search terms
Confirmed or normalized name variants
- 3'-O-(t-Butyldimethylsilyl)-2'-O-(2-methoxyethyl)-5-methyluridine
- TNU1284
- XB162363
- GL102861
Useful catalog search terms
- CAS 1221967-92-5
Physicochemical data
| SMILES | CC1=CN(C(=O)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O[Si](C)(C)C(C)(C)C)OCCOC |
|---|---|
| Sugar modification | 2'-O-(2-methoxyethyl) |
| Protection pattern | 3'-O-tert-butyldimethylsilyl |
| Base state | 5-methyluracil |
| Sugar state | beta-D-ribofuranose |
| Ribose hydroxyl state | 5' hydroxyl group unprotected |
| PubChem CID | 69030678 |
| InChIKey | QGBVVZHQUKMHOR-KCYZZUKISA-N |
| InChI | InChI=1S/C19H34N2O7Si/c1-12-10-21(18(24)20-16(12)23)17-15(26-9-8-25-5)14(13(11-22)27-17)28-29(6,7)19(2,3)4/h10,13-15,17,22H,8-9,11H2,1-7H3,(H,20,23,24)/t13-,14-,15-,17-/m1/s1 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-MOE motifs are often selected for enhanced nuclease resistance and improved duplex stability.
Method limitations
- MOE placement needs design control, especially when RNase H recruitment or steric profile matters.
These points describe 3'-O-TBDMS-2'-O-MOE-5-methyluridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
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2'-O-MOE Nucleosides · CAS: 545374-76-3
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BX-MN-01682'-O-(2-Methoxyethyl)guanosine
2'-O-MOE Nucleosides · CAS: 473278-54-5
BX-MN-01692'-O-(2-Methoxyethyl)adenosine
2'-O-MOE Nucleosides · CAS: 168427-74-5
BX-MN-01702'-O-(2-Methoxyethyl)cytidine
2'-O-MOE Nucleosides · CAS: 223777-16-0
BX-MN-01712'-O-(2-Methoxyethyl)uridine
2'-O-MOE Nucleosides · CAS: 223777-15-9
Frequently asked questions
Can the package size for 3'-O-TBDMS-2'-O-MOE-5-methyluridine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2MOE-0001 and CAS 1221967-92-5, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the 2'-O-MOE Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.