2'-O-MOE Nucleosides
3'-O-(tert-Butyldimethylsilyl)-2'-O-(2-methoxyethyl)uridine
Quick view. A protected 2'-O-MOE uridine bearing a 3'-O-tert-butyldimethylsilyl group and free 5'-hydroxyl, CAS 1345716-52-0. CAS 1345716-52-0. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
3'-O-(tert-Butyldimethylsilyl)-2'-O-(2-methoxyethyl)uridine is classified as 2'-o-moe nucleosides (Formula C18H32N2O7Si; molecular weight 416.54).
3'-O-(tert-Butyldimethylsilyl)-2'-O-(2-methoxyethyl)uridine is relevant to high-stability antisense oligonucleotide gapmer and affinity-tuning research.
For 3'-O-(tert-Butyldimethylsilyl)-2'-O-(2-methoxyethyl)uridine, mOE placement needs design control, especially when RNase H recruitment or steric profile matters.
Names and search terms
Confirmed or normalized name variants
- 3'-O-TBDMS-2'-O-MOE-uridine
Useful catalog search terms
- CAS 1345716-52-0
- Biorbyt orb1907721
- PubChem CID 168449408
Physicochemical data
| SMILES | CC(C)(C)[Si](C)(C)O[C@@H]1[C@H](O[C@H]([C@@H]1OCCOC)N2C=CC(=O)NC2=O)CO |
|---|---|
| PubChem CID | 168449408 |
| 3'-hydroxyl protection | tert-Butyldimethylsilyl (TBDMS) |
| 2'-substitution | O-(2-methoxyethyl) (MOE) |
| 5'-hydroxyl state | Unprotected |
| Nucleobase | Uracil |
| InChIKey | MVUNUYQKOFMHDC-DTZQCDIJSA-N |
| InChI | InChI=1S/C18H32N2O7Si/c1-18(2,3)28(5,6)27-14-12(11-21)26-16(15(14)25-10-9-24-4)20-8-7-13(22)19-17(20)23/h7-8,12,14-16,21H,9-11H2,1-6H3,(H,19,22,23)/t12-,14-,15-,16-/m1/s1 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-MOE motifs are often selected for enhanced nuclease resistance and improved duplex stability.
Method limitations
- MOE placement needs design control, especially when RNase H recruitment or steric profile matters.
These points describe 3'-O-(tert-Butyldimethylsilyl)-2'-O-(2-methoxyethyl)uridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
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2'-O-MOE Nucleosides · CAS: 545374-76-3
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2'-O-MOE Nucleosides · CAS: 244105-55-3
BX-MN-01682'-O-(2-Methoxyethyl)guanosine
2'-O-MOE Nucleosides · CAS: 473278-54-5
BX-MN-01692'-O-(2-Methoxyethyl)adenosine
2'-O-MOE Nucleosides · CAS: 168427-74-5
BX-MN-01702'-O-(2-Methoxyethyl)cytidine
2'-O-MOE Nucleosides · CAS: 223777-16-0
BX-MN-01712'-O-(2-Methoxyethyl)uridine
2'-O-MOE Nucleosides · CAS: 223777-15-9
Frequently asked questions
Can the package size for 3'-O-(tert-Butyldimethylsilyl)-2'-O-(2-methoxyethyl)uridine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2MOE-0004 and CAS 1345716-52-0, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the 2'-O-MOE Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.