2'-O-MOE Nucleosides
4',5'-Didehydro-2'-O-(2-methoxyethyl)uridine
Quick view. Uridine derivative bearing a 2'-O-(2-methoxyethyl) substituent and a 4',5'-exocyclic methylene unit. CAS 2095417-78-8. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
4',5'-Didehydro-2'-O-(2-methoxyethyl)uridine is classified as 2'-o-moe nucleosides (Formula C12H16N2O6; molecular weight 284.27 g/mol).
4',5'-Didehydro-2'-O-(2-methoxyethyl)uridine is relevant to high-stability antisense oligonucleotide gapmer and affinity-tuning research.
For 4',5'-Didehydro-2'-O-(2-methoxyethyl)uridine, mOE placement needs design control, especially when RNase H recruitment or steric profile matters.
Names and search terms
Useful catalog search terms
- 2095417-78-8
Physicochemical data
| Base scaffold | Uridine |
|---|---|
| Sugar modification | 4',5'-exocyclic methylene |
| 2'-substitution | O-(2-methoxyethyl) |
| InChIKey | YHEFDNRNIWVEBH-GMTAPVOTSA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-MOE motifs are often selected for enhanced nuclease resistance and improved duplex stability.
Method limitations
- MOE placement needs design control, especially when RNase H recruitment or steric profile matters.
These points describe 4',5'-Didehydro-2'-O-(2-methoxyethyl)uridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
2'-O-(2-Methoxyethyl)inosine
2'-O-MOE Nucleosides · CAS: 545374-76-3
BX-MN-01672'-O-(2-Methoxyethyl)-5-methylcytidine
2'-O-MOE Nucleosides · CAS: 244105-55-3
BX-MN-01682'-O-(2-Methoxyethyl)guanosine
2'-O-MOE Nucleosides · CAS: 473278-54-5
BX-MN-01692'-O-(2-Methoxyethyl)adenosine
2'-O-MOE Nucleosides · CAS: 168427-74-5
BX-MN-01702'-O-(2-Methoxyethyl)cytidine
2'-O-MOE Nucleosides · CAS: 223777-16-0
BX-MN-01712'-O-(2-Methoxyethyl)uridine
2'-O-MOE Nucleosides · CAS: 223777-15-9
Frequently asked questions
Can the package size for 4',5'-Didehydro-2'-O-(2-methoxyethyl)uridine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2MOE-0012 and CAS 2095417-78-8, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the 2'-O-MOE Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.