2'-O-MOE Nucleosides
5'-O-(4,4'-Dimethoxytrityl)-2'-O-(2-methoxyethyl)adenosine
Quick view. A beta-D-adenosine derivative bearing 2'-O-(2-methoxyethyl) substitution and 5'-O-DMTr protection with a free 3'-hydroxyl and unprotected N6 amino group, CAS 1384253-67-1. CAS 1384253-67-1. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
5'-O-(4,4'-Dimethoxytrityl)-2'-O-(2-methoxyethyl)adenosine is classified as 2'-o-moe nucleosides (Formula C34H37N5O7; molecular weight 627.69).
5'-O-(4,4'-Dimethoxytrityl)-2'-O-(2-methoxyethyl)adenosine is relevant to high-stability antisense oligonucleotide gapmer and affinity-tuning research.
For 5'-O-(4,4'-Dimethoxytrityl)-2'-O-(2-methoxyethyl)adenosine, mOE placement needs design control, especially when RNase H recruitment or steric profile matters.
Names and search terms
Confirmed or normalized name variants
- 5'-O-DMTr-2'-O-MOE-adenosine
Useful catalog search terms
- CAS 1384253-67-1
- MCE HY-154353
- Biorbyt orb1907663
Physicochemical data
| SMILES | COCCO[C@@H]1[C@@H]([C@H](O[C@H]1N2C=NC3=C(N=CN=C32)N)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)O |
|---|---|
| Sugar modification | 2'-O-(2-methoxyethyl) |
| 5'-hydroxyl protection | DMTr |
| 3'-hydroxyl | Free |
| N6 amino protection | Unprotected |
| PubChem CID | 98108255 |
| InChIKey | JCXHIHKUTBGDNV-JHZZHVAFSA-N |
| InChI | InChI=1S/C34H37N5O7/c1-41-17-18-44-30-29(40)27(46-33(30)39-21-38-28-31(35)36-20-37-32(28)39)19-45-34(22-7-5-4-6-8-22,23-9-13-25(42-2)14-10-23)24-11-15-26(43-3)16-12-24/h4-16,20-21,27,29-30,33,40H,17-19H2,1-3H3,(H2,35,36,37)/t27-,29-,30-,33-/m1/s1 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-MOE motifs are often selected for enhanced nuclease resistance and improved duplex stability.
Method limitations
- MOE placement needs design control, especially when RNase H recruitment or steric profile matters.
These points describe 5'-O-(4,4'-Dimethoxytrityl)-2'-O-(2-methoxyethyl)adenosine or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
2'-O-(2-Methoxyethyl)inosine
2'-O-MOE Nucleosides · CAS: 545374-76-3
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2'-O-MOE Nucleosides · CAS: 244105-55-3
BX-MN-01682'-O-(2-Methoxyethyl)guanosine
2'-O-MOE Nucleosides · CAS: 473278-54-5
BX-MN-01692'-O-(2-Methoxyethyl)adenosine
2'-O-MOE Nucleosides · CAS: 168427-74-5
BX-MN-01702'-O-(2-Methoxyethyl)cytidine
2'-O-MOE Nucleosides · CAS: 223777-16-0
BX-MN-01712'-O-(2-Methoxyethyl)uridine
2'-O-MOE Nucleosides · CAS: 223777-15-9
Frequently asked questions
Can the package size for 5'-O-(4,4'-Dimethoxytrityl)-2'-O-(2-methoxyethyl)adenosine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2MOE-0005 and CAS 1384253-67-1, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the 2'-O-MOE Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.