2'-O-MOE Nucleosides
5'-O-(4,4'-Dimethoxytrityl)-2'-O-(2-methoxyethyl)uridine
Quick view. Protected 2'-O-MOE uridine bearing a 5'-O-(4,4'-dimethoxytrityl) group with a free 3'-hydroxyl. CAS 251647-51-5. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
5'-O-(4,4'-Dimethoxytrityl)-2'-O-(2-methoxyethyl)uridine is classified as 2'-o-moe nucleosides (Formula C33H36N2O9; molecular weight 604.65 g/mol).
5'-O-(4,4'-Dimethoxytrityl)-2'-O-(2-methoxyethyl)uridine is relevant to high-stability antisense oligonucleotide gapmer and affinity-tuning research.
For 5'-O-(4,4'-Dimethoxytrityl)-2'-O-(2-methoxyethyl)uridine, mOE placement needs design control, especially when RNase H recruitment or steric profile matters.
Names and search terms
Confirmed or normalized name variants
- 5'-O-DMT-2'-O-MOE-rU
- 5'-O-DMT-2'-O-(2-methoxyethyl)uridine
Useful catalog search terms
- 251647-51-5
Physicochemical data
| Systematic name | 1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-hydroxy-3-(2-methoxyethoxy)oxolan-2-yl]pyrimidine-2,4-dione |
|---|---|
| Chemical form | Neutral 5'-O-dimethoxytrityl-protected 2'-O-MOE uridine nucleoside |
| Stereochemical scope | Ribofuranose stereocenters encoded as (2R,3R,4R,5R) |
| InChIKey | YVYKKLNOXPCFGC-PMFUCWTESA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-MOE motifs are often selected for enhanced nuclease resistance and improved duplex stability.
Method limitations
- MOE placement needs design control, especially when RNase H recruitment or steric profile matters.
These points describe 5'-O-(4,4'-Dimethoxytrityl)-2'-O-(2-methoxyethyl)uridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
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2'-O-MOE Nucleosides · CAS: 545374-76-3
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2'-O-MOE Nucleosides · CAS: 244105-55-3
BX-MN-01682'-O-(2-Methoxyethyl)guanosine
2'-O-MOE Nucleosides · CAS: 473278-54-5
BX-MN-01692'-O-(2-Methoxyethyl)adenosine
2'-O-MOE Nucleosides · CAS: 168427-74-5
BX-MN-01702'-O-(2-Methoxyethyl)cytidine
2'-O-MOE Nucleosides · CAS: 223777-16-0
BX-MN-01712'-O-(2-Methoxyethyl)uridine
2'-O-MOE Nucleosides · CAS: 223777-15-9
Frequently asked questions
Can the package size for 5'-O-(4,4'-Dimethoxytrityl)-2'-O-(2-methoxyethyl)uridine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2MOE-0016 and CAS 251647-51-5, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the 2'-O-MOE Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.