2'-O-MOE Nucleosides
N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methoxyethyladenosine
Quick view. An N6-benzoyl and 5'-O-DMT-protected 2'-O-methoxyethyl adenosine intermediate for research involving MOE-modified nucleoside chemistry. CAS 251647-48-0. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methoxyethyladenosine is classified as 2'-o-moe nucleosides (Formula C41H41N5O8; molecular weight 731.80).
N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methoxyethyladenosine — Research intermediate for 2'-O-MOE-modified nucleoside chemistry
For N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methoxyethyladenosine, storage: 2-8 C, dark and dry; confirm lot-specific documentation.
Names and search terms
Confirmed or normalized name variants
- N6-Bz-DMT-2'-O-MOE-Ar
- R1-033
Useful catalog search terms
- N6-Benzoyl-5'-O-DMT-2'-O-MOE-adenosine
- 251647-48-0
Physicochemical data
| Modification | N6-benzoyl; 5'-O-DMT; 2'-O-methoxyethyl |
|---|---|
| Physical form | White, off-white to faint yellow powder |
| SMILES | COCCO[C@@H]1[C@@H]([C@H](O[C@H]1N2C=NC3=C(N=CN=C32)NC(=O)C4=CC=CC=C4)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC)O |
| PubChem CID | 21107951 |
| InChIKey | KEVMXGNDTKPSMC-MUMPVVMASA-N |
| InChI | InChI=1S/C41H41N5O8/c1-49-22-23-52-36-35(47)33(54-40(36)46-26-44-34-37(42-25-43-38(34)46)45-39(48)27-10-6-4-7-11-27)24-53-41(28-12-8-5-9-13-28,29-14-18-31(50-2)19-15-29)30-16-20-32(51-3)21-17-30/h4-21,25-26,33,35-36,40,47H,22-24H2,1-3H3,(H,42,43,45,48)/t33-,35-,36-,40-/m1/s1 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
- 2′-O-MOE motifs are often selected for enhanced nuclease resistance and improved duplex stability.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
- MOE placement needs design control, especially when RNase H recruitment or steric profile matters.
These points describe N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methoxyethyladenosine or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
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2'-O-MOE Nucleosides · CAS: 545374-76-3
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BX-MN-01682'-O-(2-Methoxyethyl)guanosine
2'-O-MOE Nucleosides · CAS: 473278-54-5
BX-MN-01692'-O-(2-Methoxyethyl)adenosine
2'-O-MOE Nucleosides · CAS: 168427-74-5
BX-MN-01702'-O-(2-Methoxyethyl)cytidine
2'-O-MOE Nucleosides · CAS: 223777-16-0
BX-MN-01712'-O-(2-Methoxyethyl)uridine
2'-O-MOE Nucleosides · CAS: 223777-15-9
Frequently asked questions
Can the package size for N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methoxyethyladenosine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2MOE-0033 and CAS 251647-48-0, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the 2'-O-MOE Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.